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Monkeypox Vaccine Availability by Group

Monkeypox vaccine (Jynneos) supply is still limited and only available to exposed and high-risk groups described below. 

Who is eligible for monkeypox vaccine (JYNNEOS)? Due to the limited supply of vaccine, we are making it available only to those who are at highest risk.  Two groups are currently being offered vaccine; Those with known exposures, and those at highest risk for getting monkeypox based on what we have seen with the current outbreak.

For people with known exposures:

Orange County Public Health staff reach out to each person with monkeypox to find out about close contacts who would benefit from vaccination. Public Health staff reach out to those who were exposed and offer vaccine as quickly as possible.

Individuals from the following groups who feel they are at risk for monkeypox (MPX) are currently eligible and should consider receiving the MPX (JYNNEOS) vaccine:

  • Any man or trans person who has sex with men or trans persons
  • Any man or trans person who is taking or is eligible for HIV PrEP
  • Anyone living with HIV, particularly those with a CD4 count <350/mm3, an unsuppressed HIV viral load, or an opportunistic infection
  • People who have had any of the following in the past 6 months:
    • Sex at a commercial sex venue
    • Sex in association with a large public event in a geographic area where MPX transmission is occurring
  • Sexual partners of people with the above risks
  • People who anticipate experiencing the above risks, including individuals with multiple sex partners
  • Health Care Workers who are likely to collect laboratory specimens from persons with MPX (e.g., persons working in sexual health clinics or clinical settings that serve at risk populations)


How can I get vaccinated with the monkeypox vaccine (JYNNEOS)?

To get vaccinated you must attest that you meet any of the criteria above by going to where you can also book your appointment for vaccination. Booking an appointment is preferred to, just showing up, because of the vaccine supply.


When and where is Monkeypox vaccine (JYNNEOS) being offered by the County?  

OCHCA is providing 1st and 2nd doses of Jynneos vaccine (for Monkeypox) as follows:

Every Wednesday and Friday
Time: 10:00 am – 6:00 pm
Venue: SSA Central Regional Office (2020 W. Walnut Street, Santa Ana 92703). 

Scheduled appointments through or the Othena app are preferred though walk-ins are also welcome.


Last Updated: 10/21/2022