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At this time, the California Department of Public Health (CDPH) is recommending the JYNNEOS vaccine for general vaccination. There are no longer "eligibility" criteria to receive JYNNEOS vaccine, and persons who request vaccination can now receive it without having to attest to specific risk factors.

How can I get vaccinated with the Mpox vaccine (JYNNEOS)?

Orange County Health Care Agency (HCA) is providing 1st and 2nd doses of Jynneos vaccine (for mpox) as follows:

  • Monday through Friday through HCA Public Health Services Family Health Clinic
  • Time: 8:00am to 11:30am and 1:00pm to 4:00pm
  • By appointment only at 1725 W. 17th Street, Santa Ana, CA 92706

To schedule an appointment please call 1-800-914-4887 or you can also look for available appointments on

Individuals from the following groups are at increased risk for mpox and are strongly recommended to receive the mpox (JYNNEOS) vaccine:

  • Any man or trans person who has sex with men or trans persons
  • People who are eligible for HIV pre-exposure prophylaxis (PrEP)
  • Anyone living with HIV, particularly those with a CD4 count <350/mm3, an unsuppressed HIV viral load, or an opportunistic infection
  • People who have had direct skin-to-skin contact with one or more people AND who know others in their community that have had Mpox infection
  • People who have been diagnosed with a bacterial sexually transmitted disease (STD) (e.g., chlamydia, gonorrhea, syphilis) in the past 3 months
  • Sex workers
  • Sexual partners of people with the above risks
  • People who anticipate experiencing the above risks, including individuals with multiple sex partners
  • Health Care Workers who are likely to collect laboratory specimens from persons with mpox (e.g., persons working in sexual health clinics or clinical settings that serve at risk populations)